PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Tert-butyl 4-((1r,4r)-4-aminocyclohexyl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W380868CAS No.: 876371-20-9
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Boc-C-PEG3-I
0 ImagesCat. No.: HY-W577130CAS No.: 2162121-00-6
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tert-Butyl 4-(azetidin-3-yl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W056396CAS No.: 1314703-47-3
![Boc-NH-(1-Methylbicyclo[2.2.2]octane)-amino](https://file.medchemexpress.com/product_pic/hy-w358273.gif "Click to View Boc-NH-(1-Methylbicyclo[2.2.2]octane)-amino Product Detail")
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Piperazin-C-benzoic acid dihydrochloride
0 ImagesCat. No.: HY-W104938CAS No.: 86620-70-4
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1,13-Dibromotridecane
0 ImagesCat. No.: HY-W1009568CAS No.: 31772-05-1
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Piperidine-4-carbaldehyde
0 ImagesCat. No.: HY-W012935CAS No.: 50675-20-2Synonyms: Piperidine-4-carboxaldehydePiperidine-4-carbaldehyde (Piperidine-4-carboxaldehyde) is a PROTAC Linker. Piperidine-4-carbaldehyde can be used to optimize combined with the target protein affinity, thus improve the PROTAC the molecular degradation efficiency. Piperidine-4-carbaldehyde can be used in the CDK2 PROTACs (HY-161708).
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BnO-PEG3-COOH
0 ImagesCat. No.: HY-W335398CAS No.: 144751-75-7
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Tert-butyl (5-aminopentyl)(methyl)carbamate
0 ImagesCat. No.: HY-W419958CAS No.: 1228544-59-9
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m-PEG6-Hydrazide
0 ImagesCat. No.: HY-135922CAS No.: 1449390-64-0
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NHBoc-PEG3-CO-OBn
0 ImagesCat. No.: HY-W787324CAS No.: 1975173-67-1
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tert-Butyl (4-(aminooxy)butyl)carbamate
0 ImagesCat. No.: HY-W892600CAS No.: 854383-71-4
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3-(Hydroxymethyl)cyclobutanecarboxylic acid
0 ImagesCat. No.: HY-W062825CAS No.: 1015856-00-4
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Ethyl 7-aminoheptanoate
0 ImagesCat. No.: HY-W236653CAS No.: 1117-66-4
